Hydrochloric Acid → HCID 178444278, compound

Participants

Reaction Steps

A mixture of 9.88 g of 4'-[trans-4-(4-pentenyl)cyclohexyl]-4-biphenylcarbonitrile, 735 ml of diethylene glycol and 79.9 g of potassium hydroxide was heated to 150°-160° C. while stirring and gassing with nitrogen and held at this temperature for 1 hour. Subsequently, the reaction mixture was cooled to room temperature and treated with 230 ml of semi-concentrated hydrochloric acid while cooling with an ice-bath. Thereafter, the reaction mixture was poured into 1.5 l of water, stirred at room temperature for 10 minutes and then suction filtered. The residue was washed neutral with water and dried in vacuo at 60° C., whereby 10.3 g (98.5%) of 4'-[trans-4-(4-pentenyl)cyclohexyl]-4-biphenylcarboxylic acid were obtained as colourless crystals.

Provenance & Evidence