反应详情

There was dissolved 3.58 g (15.4 mmol) of methyl (-)-3-t-butyldimethylsilyloxybutyrate in 30 ml of methanol, to which 30 ml of 1 N potassium hydroxide was added and the mixture was stirred for 15 minutes. After distilling away most methanol from the mixture, the solution was acidified with 1 N hydrochloric acid and extracted with diethyl ether. The extract was washed with a saturated aqueous solution of sodium chloride and dried with anhydrous magnesium sulfate, which was concentrated under reduced pressue to give 3.18 g of (-)-3-t-butyldimethylsilyloxybutyric acid.

1. distillationAfter distilling away most methanol from the mixture
2. extractionextracted with diethyl ether
3. washThe extract was washed with a saturated aqueous solution of sodium chloride
4. dry with materialdried with anhydrous magnesium sulfate, which
5. concentrationwas concentrated under reduced pressue