Methane → HCID 136393715, compound

Participants

Reaction Steps

A solution of 9.0 g of 3'-aminomethyl-5'-bromo-4'-hydroxypropiophenone and 7.0 g of hydroxylamine hydrochloride in 50 ml of 4N sodium hydroxide solution and 15 ml of ethanol is refluxed with heating for 40 minutes. To the reaction mixture is added activated charcoal and the charcoal is filtered off and then the mixture is adjusted to pH 6-7 with concentrated hydrochloric acid. After allowing to stand at room temperature, the precipitate is collected by filtration, washed with water and dried to give 8.1 g of 3'-aminomethyl-5'-bromo-4'-hydroxypropiophenone oxime, melting at 174°-175° C. with decomposition.

Provenance & Evidence