HRID247757

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11137505

1-bromoethyl Acetate

C4H7BrO2

$结构：COC/C=C\C1=C(C(=O)O)N2C(=O)C(NC(=O)/C(=N\OC)c3csc(N)n3)[C@H]2SC1$

HCID88669300

未命名化合物

PRODUCTS

生成物

$结构：COC/C=C\C1=C(C(=O)OC(C)OC(C)=O)N2C(=O)C(NC(=O)/C(=N\OC)c3csc(N)n3)[C@H]2SC1$

HCID88668980

未命名化合物

收率 43%

PROCEDURE

实验过程

Esterification of 7-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-[(Z)-3-methoxy-1-propenyl]-3-cephem-4-carboxylic acid (300 mg, 0.66 mmole) with 1-bromoethyl acetate in a similar manner to that described in Example 10 gave the title compound (154 mg, 43%). Mp. 102°-105° C. (dec.). Estimated purity 95% (by HPLC, 1:1 CH3CN-pH 7 phosphate buffer).