HRID247763

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID887

Methanol

CH4O

HCID6212

Chloroform

CHCl3

HCID14798

Sodium Hydroxide

HNaO

$结构：CO/N=C(\C(=O)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(C[P+](c3ccccc3)(c3ccccc3)c3ccccc3)CS[C@H]12)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1.[I-]$

HCID172932298

未命名化合物

PRODUCTS

生成物

$结构：CO/N=C(\C(=O)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(C=P(c3ccccc3)(c3ccccc3)c3ccccc3)CS[C@H]12)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1$

HCID172930683

未命名化合物

收率 93%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

A solution of diphenylmethyl 7-[(Z)-2-(2-tritylaminothiazol-4-yl)-2-methoxyiminoacetamido]-3-[(triphenylphosphonio)methyl]-3-cephem-4-carboxylate iodide* (3.0 g, 2.5 m moles) in dichloromethane (40 ml) was shaken with 1N NaOH (10 ml) until the spot of the starting material disappeared on TLC (silica gel, CHCl3 --MeOH=10:1). Organic layer was separated and concentrated under reduced pressure. The residue was triturated with n-hexane and the product was collected by filtration to give 2.5 g (93%) of the title compound.

WORKUP

后处理

customOrganic layer was separated
concentrationconcentrated under reduced pressure
customThe residue was triturated with n-hexane
filtrationthe product was collected by filtration

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-78b3c045a7794887a9cc043cff610b4d
来源数据集: uspto-grants-1987_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04708955
来源说明: uspto-grants-1987_11

反应 SMILES

[I-].[C:2]([NH:21][C:22]1[S:23][CH:24]=[C:25](/[C:27](=[N:76]/[O:77][CH3:78])/[C:28]([NH:30][CH:31]2[C:74](=[O:75])[N:33]3[C:34]([C:58]([O:60][CH:61]([C:68]4[CH:73]=[CH:72][CH:71]=[CH:70][CH:69]=4)[C:62]4[CH:67]=[CH:66][CH:65]=[CH:64][CH:63]=4)=[O:59])=[C:35]([CH2:38][P+:39]([C:52]4[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=4)([C:46]4[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=4)[C:40]4[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=4)[CH2:36][S:37][C@H:32]23)=[O:29])[N:26]=1)([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[OH-].[Na+].C(Cl)(Cl)Cl.CO>ClCCl>[C:2]([NH:21][C:22]1[S:23][CH:24]=[C:25](/[C:27](=[N:76]/[O:77][CH3:78])/[C:28]([NH:30][CH:31]2[C:74](=[O:75])[N:33]3[C:34]([C:58]([O:60][CH:61]([C:68]4[CH:69]=[CH:70][CH:71]=[CH:72][CH:73]=4)[C:62]4[CH:63]=[CH:64][CH:65]=[CH:66][CH:67]=4)=[O:59])=[C:35]([CH:38]=[P:39]([C:40]4[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=4)([C:46]4[CH:47]=[CH:48][CH:49]=[CH:50][CH:51]=4)[C:52]4[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=4)[CH2:36][S:37][C@H:32]23)=[O:29])[N:26]=1)([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1)([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1