Triethyl phosphite → HCID 131717892, compound

Participants

Reaction Steps

A solution of 27 (25g, 0.1 mol) and triethyl phosphite was heated at 110° C. for 2.5 hours. After evaporation of volatile in vacuo, the residual oil was chromatographed on silica gel using CH2Cl2 -6% MeOH as eluant to give 28 (30 g, 81%) as a slightly yellow oil. 1H-NMR (300 MHz, CDCl3) 1.27 (t, J=7.24Hz, 6H), 3.01 (t, J=7.5Hz, 2H), 3.70-3.75 (m, 4H), 4.10-4.18 (m, 4H), 7.2-7.5 (m, 5H).

Provenance & Evidence