HuagongsheHuagongshe Chemistry Print Report · For research reference only
Arecoline → 3-Methoxycarbonyl-1-methyl-4-(3-trifluoromethylphenyl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Arecoline | HCID 2230 | — |
| Reactant | Benzene, 1-bromo-3-(trifluoromethyl)- | HCID 9817 | — |
| Product | 3-Methoxycarbonyl-1-methyl-4-(3-trifluoromethylphenyl)piperidine | HCID 19751261 | — |
Reaction Steps
3-methoxycarbonyl-1-methyl-4-(3-trifluoromethylphenyl)piperidine was prepared as the cis/trans mixture from arecoline and 3-bromo-trifluoromethylbenzene as described (J.Org.Chem. 22 (1957) 261). The product was purified by vacuum distillation. B.p. 90°-110° C./0.7 mmHg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05208232 |
| Source dataset | uspto-grants-1993_05 |
| ORD ID | ord-098c0fc9e82f479d951c7b70a90d1597 |
| Source note | uspto-grants-1993_05 |