Toluene → HCID 19764421, compound

Participants

Reaction Steps

To a solution of (±) phenyl nonyl phosphoryl chloride (Example C) (2.0 g, 6.3 mmol) in toluene (20 mL) at 0° C. is added a solution of benzylamine (0.67 g, 6.3 mmol) and triethylamine (1.3 mL, 9.4 mmol) in toluene (5 mL) over 5 minutes. The mixture is allowed to warm to room temperature and is stirred for 90 minutes. The mixture is filtered, and the filtrate concentrated. Flash chromatography (3:2 hexane/ethyl acetate) affords 2.1 g of the title compound as a colorless oil; 1H NMR (200 MHz, CDCl3)δ 7.40-7.10 (m, 10 H), 4.19 (dd, J=10 and 7 Hz, 2 H), 4.19-4.05 (m, 2 H), 3.20-3.00 (m, 1 H), 1.70-1.60 (m, 2 H), 1.35-1.20 (m, 12 H), 0.89 (t, J=7 Hz, 3 H).

Provenance & Evidence