HCID 9443074, compound → HCID 22390813, compound

HRID 247847Notes

Reaction equation

HRID 247847 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[F:7][C:8]1[CH:26]=[CH:25][C:11]([O:12][CH2:13][CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH:19]([C:22]([NH2:24])=O)[CH2:18][CH2:17]2)=[CH:10][CH:9]=1>O>[NH2:24][CH2:22][CH:19]1[CH2:18][CH2:17][N:16]([CH2:15][CH2:14][CH2:13][O:12][C:11]2[CH:10]=[CH:9][C:8]([F:7])=[CH:26][CH:25]=2)[CH2:21][CH2:20]1

Participants

4

Reactant 2

HCID 9443074HCID 9443074, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 22390813HCID 22390813, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3.8 grams of lithium aluminum hydride are added through a solids funnel to a suspension of 26 grams of the compound obtained in stage B. The mixture is refluxed for 2 hours. The reaction medium is decomposed using 2.6 cm3 of water and then 2.1 cm3 of sodium hydroxide and finally 9.6 cm3 of water, filtered and the filtrate is then evaporated. 13.1 grams of an oil are obtained which corresponds to the expected compound and which may be used without further purification.

Workup

  1. temperatureThe mixture is refluxed for 2 hours
  2. filtration2.1 cm3 of sodium hydroxide and finally 9.6 cm3 of water, filtered
  3. customthe filtrate is then evaporated

Sources & evidence

ORD record
ord-9881d581bc934ca1991e605271717cd2
Source dataset
uspto-grants-1993_05
Patent number
US05208243

Reaction notes

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