反应详情

To a room temperature slurry of 2.5 g of product from Example 19, 10 ml of acetonitrile and 0.339 g of pyridine is added dropwise, over 3 minutes, 2.11 g of phosphorus tribromide. The reaction is stirred at room temperature for 1 hour, diluted with methylene chloride and concentrated in vacuo. The residue is dissolved in methylene chloride, filtered through a silica gel pad and concentrated in vacuo to give 2.65 g of the desired product as pale yellow crystals.

1. concentrationconcentrated in vacuo
2. dissolutionThe residue is dissolved in methylene chloride
3. filtrationfiltered through a silica gel pad
4. concentrationconcentrated in vacuo