Acetonitrile → HCID 10045489, compound

HRID 247932Notes

Reaction equation

HRID 247932 reaction equation
[CH2:1]([O:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[CH2:22]O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].C(#N)C.P(Br)(Br)[Br:28]>N1C=CC=CC=1>[Br:28][CH2:22][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=1[O:15][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]

Participants

5

Reactant 3

HCID 6342AcetonitrileHCID 24614Phosphorus tribromideHCID 10313957HCID 10313957, compound

Product 1

HCID 10045489HCID 10045489, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
0 °C

Procedure

The title compound is prepared by the procedure of Example 20 using 2.5 g of product from Example 21, 10 ml acetonitrile, 2.11 g of phosphorus tribromide and 0.339 g of pyridine. The reaction is cooled for 10 minutes at 0° C., followed by stirring at room temperature for 1 hour. The product, 2.58 g, is obtained as cream crystals.

Workup

  1. customThe product, 2.58 g, is obtained as cream crystals

Sources & evidence

ORD record
ord-82fcabae568841aabce0bc219bfb2314
Source dataset
uspto-grants-1993_05
Patent number
US05208247

Reaction notes

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