N-(pyridin-2-ylmethyl)acetamide → HCID 10097364, compound

HRID 247958Notes

Reaction equation

HRID 247958 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[C:6](Cl)=[O:7].[N:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[CH2:33][NH:34][C:35](=[O:37])[CH3:36]>>[C:35]([N:34]([CH2:33][C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][N:27]=1)[C:6](=[O:7])[C:5]1[CH:9]=[CH:10][C:11]([O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[C:3]([O:2][CH3:1])[CH:4]=1)(=[O:37])[CH3:36]

Participants

3

Reactant 2

HCID 5084090N-(pyridin-2-ylmethyl)acetamideHCID 19014758HCID 19014758, compound

Product 1

HCID 10097364HCID 10097364, compoundYield 27.7%

Procedure

The title compound is prepared by the procedure of Example 27 using 1.09 g product from Example 48, 0.450 g of product from Example 12, 0.144 g of 50% washed sodium hydride and 12 ml of dry tetrahydrofuran. The residue is purified by column chromatography (silica gel:35% ethyl acetate/hexane) to give 0.391 g of the desired product as yellow crystals.

Workup

  1. washwashed sodium hydride and 12 ml of dry tetrahydrofuran
  2. customThe residue is purified by column chromatography (silica gel:35% ethyl acetate/hexane)

Sources & evidence

ORD record
ord-327a7cee420a498fa9a0e2179af46652
Source dataset
uspto-grants-1993_05
Patent number
US05208247

Reaction notes

Loading…