Methyl iodide → 1-Methyl-2-[2-[[4-(tetradecyloxy)benzoyl]amino]ethyl]pyridinium iodide

HRID 247968Notes

Reaction equation

HRID 247968 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][NH:9][C:10](=[O:32])[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])=[CH:13][CH:12]=1.[CH3:33][I:34]>>[I-:34].[CH3:33][N+:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][NH:9][C:10](=[O:32])[C:11]1[CH:12]=[CH:13][C:14]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 10478314N-[2-(2-Pyridinyl)ethyl]-4-(tetradecyloxy)benzamide

Product 1

HCID 100769291-Methyl-2-[2-[[4-(tetradecyloxy)benzoyl]amino]ethyl]pyridinium iodideYield 90.7%

Procedure

The title compound is prepared by the procedure of Example 28 using 0.750 g of product from Example 58 and 12.13 g of methyl iodide. The residue is recrystallized from methyl alcohol to give 0.90 g of the desired product as colorless needles.

Workup

  1. customThe residue is recrystallized from methyl alcohol

Sources & evidence

ORD record
ord-d7d158385b2747d893b6ab3612892361
Source dataset
uspto-grants-1993_05
Patent number
US05208247

Reaction notes

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