化工社化工社 化学情報印刷レポート · 研究参考用
Sodium hydride → N-(2-Pyridinylmethyl)-N-[[4-(tetradecyloxy)phenyl]methyl]acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | N-(pyridin-2-ylmethyl)acetamide | HCID 5084090 | — |
| 反応物 | 1-(Bromomethyl)-4-(tetradecyloxy)benzene | HCID 10022840 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-(2-Pyridinylmethyl)-N-[[4-(tetradecyloxy)phenyl]methyl]acetamide | HCID 10004023 | 84.9% |
反応手順
The title compound is prepared by the procedure of Example 27 using 9.4 g of product from Example 20, 3.87 g of product from Example 12, 1.24 g of 50% sodium hydride and 130 ml of dry tetrahydrofuran. The reaction is stirred at room temperature for 31/2 hours. The residue is purified by column chromatography (silica gel:60-100% ethyl acetate/hexane) to give 9.42 g of the desired product as colorless crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05208247 |
| 出典データセット | uspto-grants-1993_05 |
| ORD ID | ord-9a2a69b806da41a5ae8b6e2eec9ff139 |
| 出典メモ | uspto-grants-1993_05 |