Methyl iodide → 2-[[Acetyl[[4-(hexadecyloxy)phenoxy]acetyl]amino]methyl]-1-methylpyridinium iodide

HRID 247999Notes

Reaction equation

HRID 247999 reaction equation
[C:1]([N:4]([CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][N:34]=1)[C:5](=[O:31])[CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])=[CH:10][CH:9]=1)(=[O:3])[CH3:2].[CH3:39][I:40]>>[I-:40].[C:1]([N:4]([CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][N+:34]=1[CH3:39])[C:5](=[O:31])[CH2:6][O:7][C:8]1[CH:9]=[CH:10][C:11]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])=[CH:12][CH:13]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 19016359N-Acetyl-2-[4-(hexadecyloxy)phenoxy]-N-(2-pyridinylmethyl)acetamide

Product 1

HCID 197646732-[[Acetyl[[4-(hexadecyloxy)phenoxy]acetyl]amino]methyl]-1-methylpyridinium iodideYield 88.1%

Procedure

The title compound is prepared by the procedure of Example 28, using 0.268 g of product from Example 90 and 3.63 g of methyl iodide. The residue is crystallized from hot methyl alcohol/chloroform to give 0.30 g of the desired product as colorless needles.

Workup

  1. customThe title compound is prepared by the procedure of Example 28
  2. customThe residue is crystallized from hot methyl alcohol/chloroform

Sources & evidence

ORD record
ord-e901a5ab10ee4660b29d711f6534b39b
Source dataset
uspto-grants-1993_05
Patent number
US05208247

Reaction notes

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