反应详情

温度

100 °C

A mixture of 0.50 g of product from Example 94 and 0.184 g of 2-(aminomethyl)pyridine is heated in a sealed tube at 100° C. for 80 minutes. The crystalline reaction product is dissolved in methylene chloride, washed with 5% potassium hydroxide and saturated sodium chloride, dried and concentrated in vacuo. The residue is purified by column chromatography (silica gel: 50% ethyl acetate/hexane) to give 0.481 g of the desired product as colorless plates.

1. washwashed with 5% potassium hydroxide and saturated sodium chloride
2. customdried
3. concentrationconcentrated in vacuo
4. customThe residue is purified by column chromatography (silica gel: 50% ethyl acetate/hexane)