HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromodecane → 4-(Decyloxy)-3-(1,1-dimethylethyl)benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromodecane | HCID 8173 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 3-tert-butyl-4-hydroxybenzoate | HCID 13207060 | — |
| Catalyst | Potassium Iodide | HCID 4875 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 4-(Decyloxy)-3-(1,1-dimethylethyl)benzoic acid methyl ester | HCID 53926307 | 105.2% |
Reaction Steps
A mixture of 12.0 g of 3-(1,1-dimethylethyl)-4-hydroxybenzoic acid methyl ester, 11.15 g of 1-bromodecane, 9.95 g of potassium carbonate, 0.797 g of potassium iodide and 100 ml of 2-butanone is heated at reflux temperature for 40 hours. The reaction is cooled, filtered and the filtrate concentrated in vacuo. The residue is purified by chromatography (silica gel: 0-3% ethyl acetate/hexane) to give 18.49 g of the desired product as a light yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05208247 |
| Source dataset | uspto-grants-1993_05 |
| ORD ID | ord-72116a0f66664f80a6ae4fdf749037cf |
| Source note | uspto-grants-1993_05 |