反应详情

A mixture of 15.0 g of product from Example 130, 7.24 g of potassium hydroxide, 100 ml methyl alcohol, 40 ml ethyl alcohol and 10 ml of water is heated at reflux temperature for 18 hours. The reaction is cooled to room temperature, made acidic to pH 2, concentrated in vacuo, swirled with water and the solid collected. The solid residue is washed with water and dried in a vacuum oven to give 13 g of the desired product as colorless needles.

1. temperatureis heated
2. temperatureat reflux temperature for 18 hours
3. concentrationconcentrated in vacuo
4. customthe solid collected
5. washThe solid residue is washed with water
6. customdried in a vacuum oven