HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → N-Acetyl-4-(decyloxy)-3-(1,1-dimethylethyl)-N-(3-pyridinylmethyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-(Acetamidomethyl)pyridine | HCID 2735225 | — |
| Reactant | 3-(1,1-Dimethylethyl)-4-(tetradecyloxy)benzoyl chloride | HCID 19015370 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-Acetyl-4-(decyloxy)-3-(1,1-dimethylethyl)-N-(3-pyridinylmethyl)benzamide | HCID 19015040 | 176.3% |
Reaction Steps
The title compound is prepared by the procedure of Example 27, using 0.90 g of product from Example 33, 0.316 g of washed 50% sodium hydride, 2.57 g of product from Example 14 and 25 ml of dry tetrahydrofuran. The residue is purified by chromatography (silica gel: 40% ethyl acetate/hexane) to give 1.81 g of the desired product as a yellow oil which crystallizes on standing.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05208247 |
| Source dataset | uspto-grants-1993_05 |
| ORD ID | ord-1579ec90327a4b159e9d9f2a3956f563 |
| Source note | uspto-grants-1993_05 |