Ethyl Acetate → HCID 19014485, compound

Participants

Reaction Steps

To a 0° C. suspension of 21.0 g of product from Example 144 in 200 ml of dry tetrahydrofuran is added, dropwise over 30 minutes, 51.27 ml of 1M solution of lithium aluminum hydride in tetrahydrofuran. The reaction is stirred at room temperature for 1 hour, heated at reflux temperature for 2 hours and stirred overnight at room temperature. Ethyl acetate is added followed by concentrated sodium hydroxide. The reaction is filtered, concentrated in vacuo and the residue is recrystallized from hexane to give 16.9 g of the desired product.

Provenance & Evidence