HCID 57004089, compound → HCID 178456509, compound

HRID 248060Notes

Reaction equation

HRID 248060 reaction equation
[NH2:1][C:2]1[N:7]([CH2:8][CH2:9][CH3:10])[C:6](=[O:11])[N:5]([CH2:12][CH2:13][CH3:14])[C:4](=[O:15])[C:3]=1[NH:16][C:17](=O)[CH:18]([CH3:35])[CH2:19][C:20]1[CH:25]=[CH:24][C:23]([S:26][CH2:27][C:28]([O:30]C(C)(C)C)=[O:29])=[CH:22][CH:21]=1>C(O)C.[OH-].[K+].O>[CH2:12]([N:5]1[C:4](=[O:15])[C:3]2[N:16]=[C:17]([CH:18]([CH3:35])[CH2:19][C:20]3[CH:25]=[CH:24][C:23]([S:26][CH2:27][C:28]([OH:30])=[O:29])=[CH:22][CH:21]=3)[NH:1][C:2]=2[N:7]([CH2:8][CH2:9][CH3:10])[C:6]1=[O:11])[CH2:13][CH3:14]

Participants

5

Reactant 1

HCID 57004089HCID 57004089, compound

Product 1

HCID 178456509HCID 178456509, compound

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 962WaterSolventHCID 14797Potassium HydroxideSolvent

Conditions

Temperature
55 °C

Procedure

Dissolve 2-[[4-[3-[(6-amino-1-propyl-1,2,3,4-tetrahydro-3-propyl-2,4-dioxo-5-pyrimidinyl)amino]-2-methyl-3-oxopropyl]phenyl]thio]-acetic acid, 1,1-dimethylethyl ester (1.65 g, 3.18 mmol) in a mixture of ethanol (30 mL) and 15% potassium hydroxide (30 mL). Heat at 55° C. and stir for several hours. Cool, acidify and dilute with water (200 mL). Filter the precipitate and dry to give the title compound.

Workup

  1. temperatureCool
  2. filtrationFilter the precipitate
  3. customdry

Sources & evidence

ORD record
ord-a73696d292ee44cca928ea79478b3215
Source dataset
uspto-grants-1993_05
Patent number
US05208240

Reaction notes

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