HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Diethyl methyl-(4-amino)benzylmalonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Bicarbonate Ion | HCID 769 | — |
| Reactant | Diethyl methyl-(4-acetamido)benzylmalonate | HCID 54008305 | — |
| Product | Diethyl methyl-(4-amino)benzylmalonate | HCID 54055855 | — |
Reaction Steps
Mix diethyl methyl-(4-acetamido)benzylmalonate (5.01 g, 15.6 mmol) and 2N hydrochloric acid (65 mL) and heat at reflux for several hours. Cool to room temperature, basify with solid hydrogen carbonate and extract into ethyl ether (3×). Dry (MgSO4) and evaporate the solvent in vacuo to give diethyl methyl-(4-amino)benzylmalonate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05208240 |
| Source dataset | uspto-grants-1993_05 |
| ORD ID | ord-05b0ce8b6270496ab4525a8a2b7e8ddd |
| Source note | uspto-grants-1993_05 |