Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | HCID 178456495 | HCID 178456495 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 178456497 | HCID 178456497 | — |
Reaction Steps
Dissolve 2-[4-[2-(2,3,6,9-tetrahydro-1,3-dipropyl-2,6-dioxo-1H-purin-8-yl)propyl]phenylamino]acetic acid (85.4 g, 0.2 mol) in methanol (500 mL) and treat with concentrated sulfuric acid (0.5 mL). Heat to 60° C. for 16 hours, cool and reduce the solvent by 50% in vacuo. Dilute with ethyl ether (500 mL), wash with saturated sodium hydrogen carbonate, then brine. Dry (MgSO4) and evaporate the solvent in vacuo to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05208240 |
|---|
| Source dataset | uspto-grants-1993_05 |
|---|
| ORD ID | ord-9aa6e3e31c834b8492507d1e3ab9e029 |
|---|
| Source note | uspto-grants-1993_05 |
|---|
