反应详情

Dissolve methyl 4-mercaptophenylacetate (16.4 g, 90.3 mmol) in acetone (300 mL). Add potassium carbonate (13.7 g, 99.3 mmol), potassium iodide (1.47 g, 9.03 mmol) and t-butylbromoacetate (16 mL, 99.3 mmol). Heat at reflux for 20 hours then remove 200 mL of acetone in vacuo. Dilute the residue with ethyl ether (500 mL), wash with water (2×300 mL) and brine (300 mL). Dry (MgSO4) and evaporate the solvent in vacuo. Purify by flash chromatography to give the title compound.

1. temperatureHeat
2. temperatureat reflux for 20 hours
3. customthen remove 200 mL of acetone in vacuo
4. additionDilute the residue with ethyl ether (500 mL)
5. washwash with water (2×300 mL) and brine (300 mL)
6. dry with materialDry (MgSO4)
7. customevaporate the solvent in vacuo
8. customPurify by flash chromatography