反应详情

Dissolve (-)-2-[4-[2-(2,3,6,9-tetrahydro-1,3-dipropyl-2,6-dioxo-1H-purin-8-yl)propyl]phenoxy]acetic acid, ethyl ester (0.62 g, 1.36 mmol) in ethanol (15 mL) and treat with a solution of potassium hydroxide (0.091 g, 1.63 mmol) in water (15 mL). Stir for 3 hours, add water (200 mL) and wash with ethyl ether (300 mL). Acidify the aqueous phase with 10% hydrochloric acid and extract into chloroform (4×150 mL). Dry (MgSO4) and evaporate the solvent in vacuo to give the title compound (0.47 g, 81%); [α]d 20 =-79.1° (C=0.537, DMSO).

1. washwash with ethyl ether (300 mL)
2. extractionextract into chloroform (4×150 mL)
3. dry with materialDry (MgSO4)
4. customevaporate the solvent in vacuo