Methyl iodide → HCID 19764821, compound

HRID 248102Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([S:13][C:14]2[CH:15]=[C:16]([C:20]3([O:26][CH3:27])[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)[CH:17]=[CH:18][CH:19]=2)[CH:5]=[CH:6][C:7]=1[NH:8][C:9](=[O:12])[CH2:10][CH3:11].[CH3:28]I>>[Cl:1][C:2]1[CH:3]=[C:4]([S:13][C:14]2[CH:15]=[C:16]([C:20]3([O:26][CH3:27])[CH2:21][CH2:22][O:23][CH2:24][CH2:25]3)[CH:17]=[CH:18][CH:19]=2)[CH:5]=[CH:6][C:7]=1[N:8]([CH3:28])[C:9](=[O:12])[CH2:10][CH3:11]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 19764822HCID 19764822, compound

Product 1

HCID 19764821HCID 19764821, compoundYield 67%

Procedure

Using a similar procedure to that described in Example 18, 4-[3-(3-chloro-4-propionamidophenylthio)phenyl]-4-methoxytetrahydropyran was reacted with methyl iodide to give 4-[3-(3-chloro-4-(N-methylpropionamido)phenylthio)phenyl]-4-methoxytetrahydropyran in 67% yield as a gum.

Sources & evidence

ORD record: ord-26dd5c2475ad4167995668577ee4411d
Source dataset: uspto-grants-1993_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05208259

Reaction notes

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