Methyl iodide → HCID 19764802, compound

HRID 248103Notes

Reaction equation

[C:1]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([S:16][C:17]2[CH:18]=[C:19]([C:23]3([O:29][CH3:30])[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)[CH:20]=[CH:21][CH:22]=2)=[CH:12][C:11]=1[Cl:31])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:32]I>>[Cl:31][C:11]1[CH:12]=[C:13]([S:16][C:17]2[CH:18]=[C:19]([C:23]3([O:29][CH3:30])[CH2:24][CH2:25][O:26][CH2:27][CH2:28]3)[CH:20]=[CH:21][CH:22]=2)[CH:14]=[CH:15][C:10]=1[N:9]([CH3:32])[C:1](=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 19764797HCID 19764797, compound

Product 1

HCID 19764802HCID 19764802, compoundYield 86%

Procedure

Using a similar procedure to that described in Example 18, 4-[3-(4-benzamido-3-chlorophenylthio)phenyl]-4-methoxytetrahydropyran was reacted with methyl iodide to give 4-[3-(3-chloro-4-(N-methylbenzamido)phenylthio)phenyl]-4-methoxytetrahydropyran in 86% yield as a gum.

Sources & evidence

ORD record: ord-60458b549d3541d79918381cdbccdfeb
Source dataset: uspto-grants-1993_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05208259

Reaction notes

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