HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-(Hexadecyloxy)-2-(hexadecylthio)methyl-1-propanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium borohydride | HCID 4148881 | — |
| Reactant | Ethyl 3-(hexadecyloxy)-2-[(hexadecylthio)methyl]propanoate | HCID 19764340 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(Hexadecyloxy)-2-(hexadecylthio)methyl-1-propanol | HCID 19764327 | 68.1% |
Reaction Steps
To a slurry of 1.04 g of lithium borohydride in 20 ml of tetrahydrofuran is added 29 g of 3-(hexadecyl-oxy)-2-[(hexadecylthio)methyl]propanoic acid, ethyl ester. This mixture is refluxed overnight, poured into water and purified by chromatography on silica gel [hexane:ethyl acetate (30:1)], to give 18.4 g of the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05208223 |
| Source dataset | uspto-grants-1993_05 |
| ORD ID | ord-86fdf7ae4c794f358f3ce83b02b15984 |
| Source note | uspto-grants-1993_05 |