Water → 3-Hexadecyloxy-2-methylenepropan-1-ol

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Reaction Steps

To 18.5 g of washed sodium hydride in 500 ml of dry dimethylformamide in a water bath is added dropwise, 67.4 g of 2-butene-1,2-diol. A solution of 235 g of hexadecylbromide in 100 ml of dimethylformamide is added dropwise. This mixture is stirred at room temperature for 2 days then poured into water and extracted with ether. The ether extract is separated, dried, evaporated and purified by chromatography, to give 30 g of the desired compound.

Provenance & Evidence