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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 24815Generated: October 26, 2026

Sodium Hydroxide → HCID 178480921, compound

https://huagongshe.com/reaction/24815

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium HydroxideHCID 14798—
ReactantN-(4-Aminophenyl)-2-(4-methylpiperazin-1-YL)acetamideHCID 16778876—
Reactant1-Acetyl-3-{1-ethoxy-1-phenylmethylidene}-5-nitro-2-indolinoneHCID 54280104—
SolventMethanolHCID 887—
SolventDimethylformamideHCID 6228—
ProductHCID 178480921HCID 178480921—

Reaction Steps

Prepared analogously to Example 82 from 1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-5-nitro-2-indolinone and 4-(4-methylpiperazinomethylcarbonylamino)-aniline in DMF and subsequent treatment with sodium hydroxide solution in methanol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06855710B2
Source datasetuspto-grants-2005_02
ORD IDord-aa7c9bfb43554fd4bdcb6b598b1e310a
Source noteuspto-grants-2005_02