HRID24820

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID521305

1-Chloroethyl carbonochloridate

C3H4Cl2O2

$结构：CN(C(=O)CN1CCN(Cc2ccccc2)CC1)c1ccc(N/C(=C2\C(=O)Nc3ccc([N+](=O)[O-])cc32)c2ccccc2)cc1$

HCID178485770

未命名化合物

PRODUCTS

生成物

$结构：CN(C(=O)CN1CCNCC1)c1ccc(N/C(=C2\C(=O)Nc3ccc([N+](=O)[O-])cc32)c2ccccc2)cc1.Cl.Cl$

HCID178485768

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Prepared analogously to Example 54 from (Z)-3-{1-[4-(N-(4-benzylpiperazinomethylcarbonyl)-N-methyl-amino)-phenylamino]-1-phenyl-methylidene}-5-nitro-2-indolinone and 1-chloroethyl chloroformate in dichloromethane.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-354dbdbed1c745f78f285095acce9cf3
来源数据集: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06855710B2
来源说明: uspto-grants-2005_02

反应 SMILES

C([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]([N:17]([C:19]2[CH:24]=[CH:23][C:22]([NH:25]/[C:26](=[C:33]3\[C:34](=[O:45])[NH:35][C:36]4[C:41]\3=[CH:40][C:39]([N+:42]([O-:44])=[O:43])=[CH:38][CH:37]=4)/[C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[CH:21][CH:20]=2)[CH3:18])=[O:16])[CH2:10][CH2:9]1)C1C=CC=CC=1.[Cl:46]C(OC(Cl)C)=O>ClCCl>[ClH:46].[ClH:46].[N:11]1([CH2:14][C:15]([N:17]([C:19]2[CH:20]=[CH:21][C:22]([NH:25]/[C:26](=[C:33]3\[C:34](=[O:45])[NH:35][C:36]4[C:41]\3=[CH:40][C:39]([N+:42]([O-:44])=[O:43])=[CH:38][CH:37]=4)/[C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)=[CH:23][CH:24]=2)[CH3:18])=[O:16])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1