Acetoxyacetyl chloride → HCID 57121951, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 17-ethyl-1,14-dihydroxy-12-[2'-(4"-amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-18-ene-2,3,10,16-tetraone (40 mg) in dry methylene chloride (0.4 ml) was cooled to 0° C. To this solution was added a solution of acetoxyacetyl chloride (9 mg) in methylene chloride (0.5 ml). The reaction mixture was stirred at 0° C. for 30 minutes, and quenched with a drop of methanol. Purification by preparative tlc on silica gel (1000 microns, 5% i-PrOH/CH2Cl2) gave 36 mg of the title compound.

Provenance & Evidence