HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 248260Generated: October 31, 2026
2-Bromo-1,1-dimethoxyethane → HCID 86746812, compound
https://huagongshe.com/reaction/248260
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Bromo-1,1-dimethoxyethane | HCID 81672 | — |
| Reactant | 17-Ethyl-1-hydroxy-12-[2'-(4"-azido-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetraone | HCID 86746808 | — |
| Catalyst | Silver(II) oxide | HCID 92152 | — |
| Product | HCID 86746812 | HCID 86746812 | — |
Reaction Steps
A suspension of 17-ethyl-1-hydroxy-12-[2'-(4"-azido-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-18-ene-2,3,10,16-tetraone (25 mg, Example 42) and silver oxide (25 mg) in 2 ml of bromoacetaldehyde dimethyl acetal is heated at 70° C. for 4 days. The solids are removed by filtration, washed with ethyl acetate, and concentrated in vacuo. The resulting oil is purified by preparative tlc on silica gel to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05208228 |
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| Source dataset | uspto-grants-1993_05 |
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| ORD ID | ord-3295fd512ce0413aaac912f590f532b7 |
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| Source note | uspto-grants-1993_05 |
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