Sodium Hydroxide → HCID 19763330, compound

Participants

Reaction Steps

A solution of 10.4 g (0.0432 mol) of 6-chloro-9-(2-carbomethoxyethyl)purine in 400 mL dioxane, 20 mL H2O and 50 mL N NaOH was stirred 2 h at room temperature. Nearly all the solvent was removed by roto-evaporation and 50 mL of N HCl was added. The mixture was chilled and the precipitate collected; 9.00 g (92%); recrystallized from methanol-petroleum ether; mp 163°-165°; 1H NMR (200 MHz, DMSO-d6) δ8.80 (1H, s, 7 or 8-H), 4.52(2H, t), 2.97 (2H, t, CH2CO).

Provenance & Evidence