反应详情

温度

0 °C

9.5 g (0.017 mol) of 4-[(5-chloro-2-methoxyphenoxy)methyl]-N-(triphenylmethyl)-1-piperidinepropanamine are suspended in 215 ml of methanol. The reaction mixture is cooled to 0° C. and gaseous hydrochloric acid is bubbled in. The reaction mixture is allowed to return to room temperature and is evaporated to dryness, and the product obtained is recrystallised in an MeOH/AcOEt (50 ml:150 ml) mixture. Yield: 84.9%, M.p. 153°-157° C.

1. customgaseous hydrochloric acid is bubbled in
2. customto return to room temperature
3. customis evaporated to dryness
4. customthe product obtained
5. customis recrystallised in an MeOH/AcOEt (50 ml:150 ml) mixture