Chloroacetonitrile → HCID 20093009, compound

Participants

Reaction Steps

A mixture of 2-hydroxy-4'-methylbenzophenone (18.3 g), chloroacetonitrile (7.87 g) and potassium carbonate (14.2 g) in N,N'-dimethylformamide (183 ml) was stirred at ambient temperature for 5 hours and then poured into ice water. The separated oil was extracted with dichloromethane (×2). The organic layer were washed with water (×3), dried and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel eluted with dichloromethane to give 2-cyanomethoxy-4'-methylbenzophenone (21.3 g) as a yellow oil.

Provenance & Evidence