反应详情

A 4.7 g portion of 2-dimethylaminomethyl-1,4-bis(phenylmethyl)piperazine was dissolved in a mixture of 50 ml of ethanol, 20 ml of cyclohexane and 10 ml of glacial acetic acid. A 2.0 g portion of 10% palladium on carbon was added, the mixture was refluxed overnight and then filtered. The filtrate was evaporated, 5 ml of saturated aqueous potassium bicarbonate was added to the residue and this was extracted several times with dichloromethane. The extracts were combined, dried, filtered and evaporated, giving a gum which solidified on standing, giving 1.02 g of N,N-dimethyl-2-piperazinemethanamine.

1. temperaturethe mixture was refluxed overnight
2. filtrationfiltered
3. customThe filtrate was evaporated
4. addition5 ml of saturated aqueous potassium bicarbonate was added to the residue
5. extractionthis was extracted several times with dichloromethane
6. customdried
7. filtrationfiltered
8. customevaporated
9. customgiving a gum which