反应详情

温度

130 °C

A mixture of 2 g of 3-phenoxymethylpiperazine and 701 mg of 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid in 10 ml of pyridine was heated under argon in a pressure bottle at 130° C. for 18 hours. The solvents were removed and the residue chromatographed on silica gel, eluting with chloroform:methanol (9:1). The appropriate fractions were combined, evaporated, triturated with methanol and ether, then dried, giving 519 mg of the desired compound, mp 198°-200° C.

1. customThe solvents were removed
2. customthe residue chromatographed on silica gel
3. washeluting with chloroform:methanol (9:1)
4. customevaporated
5. customtriturated with methanol and ether
6. customdried