反应详情

A solution of 8.2 g of ethylenediamine in 250 ml of ethanol was added to a solution of 17.64 g of the above aldehyde in 250 ml of ethanol at 0° C. This mixture was stirred at room temperature for 1.5 hours, recooled to 0° C. and 9.6 g of sodium borohydride was added. This mixture was stirred overnight, quenched with water and the ethanol removed. The residue was extracted with dichloromethane, washed with water, dried and evaporated. The residue was crystallized with ether-hexane, giving 12 g of 2-(2-thienyl)piperazine.

1. customrecooled to 0° C.
2. stirringThis mixture was stirred overnight
3. customquenched with water
4. customthe ethanol removed
5. extractionThe residue was extracted with dichloromethane
6. washwashed with water
7. customdried
8. customevaporated
9. customThe residue was crystallized with ether-hexane