反应详情

A mixture of 2.508 g of 2-(2-furanyl)piperazine, 942 mg of 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and 10 ml of pyridine was refluxed for 24 hours, then the solvent was removed. The residue was triturated with ether and chloroform, the solid collected, dissolved in 40% acetic acid and adjusted to pH 7 with 1N sodium hydroxide. The resulting solid was collected, washed with methanol and ether and dried, giving 600 mg of the desired product, mp 198° C.

1. temperaturewas refluxed for 24 hours
2. customthe solvent was removed
3. customThe residue was triturated with ether and chloroform
4. customthe solid collected
5. dissolutiondissolved in 40% acetic acid
6. customThe resulting solid was collected
7. washwashed with methanol and ether
8. customdried