Formaldehyde → HCID 14839368, compound

HRID 248482Notes

Reaction equation

HRID 248482 reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:24])=[C:10]([N:13]3[CH2:18][CH2:17][NH:16][CH:15]([C:19]4[S:20][CH:21]=[CH:22][CH:23]=4)[CH2:14]3)[CH:11]=2)[C:6](=[O:25])[C:5]([C:26]([OH:28])=[O:27])=[CH:4]1)[CH3:2].[CH2:29]=O>C(O)=O>[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:24])=[C:10]([N:13]3[CH2:18][CH2:17][N:16]([CH3:29])[CH:15]([C:19]4[S:20][CH:21]=[CH:22][CH:23]=4)[CH2:14]3)[CH:11]=2)[C:6](=[O:25])[C:5]([C:26]([OH:28])=[O:27])=[CH:4]1)[CH3:2]

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 14839367HCID 14839367, compound

Product 1

HCID 14839368HCID 14839368, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A mixture of 200 mg of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[3-(2-thienyl)-1-piperazinyl]-3-quinolinecarboxylic acid, 0.3 ml of 37% formalin and 0.35 ml of 90% formic acid was refluxed for 2 hours, then evaporated. A ml portion of water was added and the mixture neutralized with 1N sodium hydroxide. The solid was collected, washed with water, methanol, ether and dried, giving mg of the desired product, mp 238°-240° C.

Workup

  1. temperaturewas refluxed for 2 hours
  2. customevaporated
  3. additionA ml portion of water was added
  4. customThe solid was collected
  5. washwashed with water, methanol, ether
  6. customdried

Sources & evidence

ORD record
ord-a05715a23b0b460daa3c7996d1a766d2
Source dataset
uspto-grants-1993_05
Patent number
US05210193

Reaction notes

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