反应详情

A mixture of 2.35 g of 2-(2,5-dimethyl-3-thienyl)piperazine and 1.076 g of 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid in 10 ml of pyridine was heated for 48 hours, then cooled and filtered. The filtrate was evaporated under reduced pressure and the residue triturated with chloroform:methanol (9:1),. giving 800 mg of the desired product, mp 248°-250° C.

1. temperaturewas heated for 48 hours
2. temperaturecooled
3. filtrationfiltered
4. customThe filtrate was evaporated under reduced pressure
5. customthe residue triturated with chloroform:methanol (9:1)