HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → tert-butyl N-[2-[[3-[[(Z)-(5-nitro-2-oxo-1H-indol-3-ylidene)-phenylmethyl]amino]phenyl]methylamino]-2-oxoethyl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-Acetyl-3-{1-ethoxy-1-phenylmethylidene}-5-nitro-2-indolinone | HCID 54280104 | — |
| Reactant | 3-Tert.butoxycarbonylaminomethylcarbonylaminomethyl-aniline | HCID 69740325 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | tert-butyl N-[2-[[3-[[(Z)-(5-nitro-2-oxo-1H-indol-3-ylidene)-phenylmethyl]amino]phenyl]methylamino]-2-oxoethyl]carbamate | HCID 178453820 | — |
Reaction Steps
Prepared analogously to Example 82 from 1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-5-nitro-2-indolinone and 3-tert.butoxycarbonylaminomethylcarbonylaminomethyl-aniline in DMF and subsequent treatment with sodium hydroxide solution in methanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06855710B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-1192152176d5492e9b3719b88a81c5d9 |
| Source note | uspto-grants-2005_02 |