Sodium Hydroxide → HCID 14839385, compound

HRID 248498Notes

Reaction equation

HRID 248498 reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:34])=[C:10]([N:13]3[CH2:18][CH2:17][N:16]([CH3:19])[CH:15]([C:20]4[CH:24]=[CH:23][N:22](S(C5C=CC=CC=5)(=O)=O)[CH:21]=4)[CH2:14]3)[CH:11]=2)[C:6](=[O:35])[C:5]([C:36]([OH:38])=[O:37])=[CH:4]1)[CH3:2].[OH-].[Na+]>O1CCOCC1>[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:34])=[C:10]([N:13]3[CH2:18][CH2:17][N:16]([CH3:19])[CH:15]([C:20]4[CH:24]=[CH:23][NH:22][CH:21]=4)[CH2:14]3)[CH:11]=2)[C:6](=[O:35])[C:5]([C:36]([OH:38])=[O:37])=[CH:4]1)[CH3:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 14839379HCID 14839379, compound

Product 1

HCID 14839385HCID 14839385, compoundYield 72.9%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 538 mg of 1-ethyl-6-fluoro-1,4-dihydro-7-[4-methyl-3-[1-(phenylsulfonyl)-1H-pyrrol-3-yl]-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid, 5 ml of 1N sodium hydroxide and 15 ml of dioxane was reacted as described in Example 56, giving 290 mg of the desired product, mp 150°-152° C.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-1c1414279c4b479187a0e2b126707858
Source dataset
uspto-grants-1993_05
Patent number
US05210193

Reaction notes

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