Hydrogen chloride-ethyl acetate → HCID 178479240, compound

HRID 24850Notes

Reaction equation

C(OC([NH:8][CH2:9][C:10]([NH:12][CH2:13][C:14]1[CH:15]=[C:16]([NH:20]/[C:21](=[C:28]2\[C:29](=[O:40])[NH:30][C:31]3[C:36]\2=[CH:35][C:34]([N+:37]([O-:39])=[O:38])=[CH:33][CH:32]=3)/[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:17]=[CH:18][CH:19]=1)=[O:11])=O)(C)(C)C.C(OCC)(=O)C.[ClH:47]>>[ClH:47].[NH2:8][CH2:9][C:10]([NH:12][CH2:13][C:14]1[CH:15]=[C:16]([NH:20]/[C:21](=[C:28]2\[C:29](=[O:40])[NH:30][C:31]3[C:36]\2=[CH:35][C:34]([N+:37]([O-:39])=[O:38])=[CH:33][CH:32]=3)/[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:17]=[CH:18][CH:19]=1)=[O:11]

Participants

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetate

HCID 178453820tert-butyl N-[2-[[3-[[(Z)-(5-nitro-2-oxo-1H-indol-3-ylidene)-phenylmethyl]amino]phenyl]methylamino]-2-oxoethyl]carbamate

Product 1

HCID 178479240HCID 178479240, compound

Procedure

Prepared analogously to Example 29a from (Z)-3-[1-(3-tert.butoxycarbonylaminomethylcarbonylaminomethyl-phenylamino)-1-phenyl-methylidene]-5-nitro-2-indolinone and ethyl acetate/hydrogen chloride.

Sources & evidence

ORD record: ord-983c59b70db740678ee55252800c21e7
Source dataset: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06855710B2

Reaction notes

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