HRID248508

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID800521

1-ethyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

C12H9F2NO3

HCID19763547

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCOCC1CN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3CC)CCN1

HCID14839390

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1049

Pyridine

C5H5N

溶剂HCID3283

Diethyl Ether

C4H10O

PROCEDURE

实验过程

A 710 mg portion of 1-ethyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid was suspended in 5 ml of pyridine and 2 g of 2-[(dodecyloxy)methyl]-piperazine added. This mixture was heated at 80°-85° C. for 4 hours, then cooled and diluted with ether. The solid was collected, washed with ether and dried, giving 1.3 g of the desired product, mp 125°-127° C.

WORKUP

后处理

temperatureThis mixture was heated at 80°-85° C. for 4 hours
temperaturecooled
customThe solid was collected
washwashed with ether
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b3be4af5200e4be6bb03f644195b131c
来源数据集: uspto-grants-1993_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05210193
来源说明: uspto-grants-1993_05

反应 SMILES

[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:14])=[C:10](F)[CH:11]=2)[C:6](=[O:15])[C:5]([C:16]([OH:18])=[O:17])=[CH:4]1)[CH3:2].[CH2:19]([O:31][CH2:32][CH:33]1[CH2:38][NH:37][CH2:36][CH2:35][NH:34]1)[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30]>N1C=CC=CC=1.CCOCC>[CH2:19]([O:31][CH2:32][CH:33]1[NH:34][CH2:35][CH2:36][N:37]([C:10]2[CH:11]=[C:12]3[C:7]([C:6](=[O:15])[C:5]([C:16]([OH:18])=[O:17])=[CH:4][N:3]3[CH2:1][CH3:2])=[CH:8][C:9]=2[F:14])[CH2:38]1)[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30]