HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[3-(3-furanyl)-1-piperazinyl]-3-quinolinecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 800521 | — |
| Reactant | 2-(Furan-3-yl)piperazine | HCID 19763537 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[3-(3-furanyl)-1-piperazinyl]-3-quinolinecarboxylic acid | HCID 14839394 | 32% |
Reaction Steps
A mixture of 592 mg of 3-(3-furanyl)piperazine, 329 mg of 1-ethyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and 8 ml of pyridine was heated in a pressure bottle at 95°-100° C. for 18 hours and then purified as described in Example 65, giving 160 mg of the desired product, mp 202°-204° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05210193 |
| Source dataset | uspto-grants-1993_05 |
| ORD ID | ord-7a8c1ba648ce4298817708923f8559a9 |
| Source note | uspto-grants-1993_05 |