Fluoroquinolonic acid → HCID 14839412, compound

HRID 248519Notes

Reaction equation

HRID 248519 reaction equation
Cl[C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:18])[C:7]([C:15]([OH:17])=[O:16])=[CH:8][N:9]2[CH:12]2[CH2:14][CH2:13]2)=[CH:4][C:3]=1[F:19].[CH:20]1([CH:23]2[NH:28][CH2:27][CH2:26][NH:25][CH2:24]2)[CH2:22][CH2:21]1>N1C=CC=CC=1>[CH:20]1([CH:23]2[NH:28][CH2:27][CH2:26][N:25]([C:2]3[CH:11]=[C:10]4[C:5]([C:6](=[O:18])[C:7]([C:15]([OH:17])=[O:16])=[CH:8][N:9]4[CH:12]4[CH2:14][CH2:13]4)=[CH:4][C:3]=3[F:19])[CH2:24]2)[CH2:22][CH2:21]1

Participants

4

Reactant 2

HCID 483180Fluoroquinolonic acidHCID 197635402-Cyclopropylpiperazine

Product 1

HCID 14839412HCID 14839412, compoundYield 17.5%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
140 °C

Procedure

A mixture of 787 mg of 7-chloro-1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo-3-quinolinecarboxylic acid, 1.736 g of 3-cyclopropylpiperazine and 8 ml of pyridine was heated at 140° C. in a pressure bottle for 18 hours and then purified as described in Example 95, giving 182 mg of the desired product, mp 245° C. (dec.).

Workup

  1. custompurified

Sources & evidence

ORD record
ord-ff10b4db123e473d88a1cab328c9a25a
Source dataset
uspto-grants-1993_05
Patent number
US05210193

Reaction notes

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