HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 248524Generated: October 31, 2026
1-Ethyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → HCID 23042962, compound
https://huagongshe.com/reaction/248524
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Ethyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 800521 | — |
| Reactant | HCID 19763589 | HCID 19763589 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 23042962 | HCID 23042962 | 13.2% |
Reaction Steps
A mixture of 1.12 g of 1-ethyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, 1.95 g of 3-ethynylpiperazine and 15 ml of pyridine is heated at 100° C. in a pressure bottle for 3 hours, then cooled and evaporated. The residue is purified by silica gel flash chromatography, eluting with chloroform:methanol:water:triethylamine (9:0.5:0.02:0.02), giving 200 mg of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05210193 |
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| Source dataset | uspto-grants-1993_05 |
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| ORD ID | ord-10098270bc8b425ba698e0a39b1ba86b |
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| Source note | uspto-grants-1993_05 |
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