Formaldehyde → HCID 23042972, compound

HRID 248526Notes

Reaction equation

HRID 248526 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:22])=[C:11]([N:14]4[CH2:19][CH2:18][NH:17][CH:16]([C:20]#[CH:21])[CH2:15]4)[CH:12]=3)[C:7](=[O:23])[C:6]([C:24]([OH:26])=[O:25])=[CH:5]2)[CH2:3][CH2:2]1.[CH2:27]=O>C(O)=O>[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:22])=[C:11]([N:14]4[CH2:19][CH2:18][N:17]([CH3:27])[CH:16]([C:20]#[CH:21])[CH2:15]4)[CH:12]=3)[C:7](=[O:23])[C:6]([C:24]([OH:26])=[O:25])=[CH:5]2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 19763613HCID 19763613, compound

Product 1

HCID 23042972HCID 23042972, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A mixture of 200 mg of 1-cyclopropyl-7-(3-ethynyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, 0.3 ml of 90% formic acid and 0.24 ml of 37% formalin is heated for 2 hcurs, then evaporated. The residue is diluted with water, nuetralized to pH 7 with 1N sodium hydroxide, the solid collected, and washed with water, ether and dried in vacuo, giving 156 mg of the desired product.

Workup

  1. temperatureis heated for 2 hcurs
  2. customevaporated
  3. additionThe residue is diluted with water
  4. customthe solid collected
  5. washwashed with water, ether
  6. customdried in vacuo

Sources & evidence

ORD record
ord-612094786ba24cb0bc3b99c7f17b7d91
Source dataset
uspto-grants-1993_05
Patent number
US05210193

Reaction notes

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